Fig. 5C summarizes the precision that the strategy predicts nucleosome ranks (or equivalently the brand new ranks of one’s dyad axis). Instead of regarding former coarse mathematical predictions on the genomic measure (Fig. 3), right here the bottom-pair peak prediction reliability try impacted by having fun with a first theme construction other than this new amazingly construction (25). Including moderating the extreme series dependency of nucleosome formation opportunity, Fig. 5B means that new methylation perception utilizes succession label. The perception range out-of having a failing impact (target succession 601) to causing a whole option for the nucleosome-binding preference (target succession poultry ?-globulin).

In the place of the absolute most accurate succession degree oriented tips (thirteen ? –15), our experience degree-totally free because it does not mine employing one statistical investigation for the sometimes succession otherwise architectural patterns one to correlate that have nucleosome ranking.